Several studies have reported associations between lipid parameters and clinical progression of HIV
infection. We performed a cross-sectional study including 468 antiretroviral-treated HIV-infected
patients to investigate the impact of 13 polymorphisms of 9 genes affecting lipid metabolism and CD4
and CD8-T cell levels. ...»»»»
Several studies have reported associations between lipid parameters and clinical progression of HIV
infection. We performed a cross-sectional study including 468 antiretroviral-treated HIV-infected
patients to investigate the impact of 13 polymorphisms of 9 genes affecting lipid metabolism and CD4
and CD8-T cell levels. Polymorphisms were identified in genes selected for their role in the development
of atherogenic dyslipidemia, defined as triglycerides P1.7 mmol/L and high-density lipoprotein cholesterol
(HDLc) <1.02 in women or 1.28 mmol/L in men. Lipid and lipoprotein parameters were determined
in all participants, as well as CD4 and CD8 T-cell counts. ANOVA was performed to compare the mean
values of lipid and CD4 and CD8 T-cell count data. A Bonferroni correction for multiple comparisons
was applied. 468 patients were included, 148 of them had a diagnosis of atherogenic dyslipidemia. The
polymorphism rs3135506 in APOA5 was associated with a 9% increase in triglycerides (p = 0.002), 10%
and 21% decrease in HDLc (p = 0.005), and CD4 T-cell count (p = 0.024), respectively. APOA5 rs662799,
was associated with a 19% increase in CD8 T-cell count (p = 0.002). Carriers of LPL rs328 in the dyslipidemic
group presented 11% higher levels of HDLc (p = 0.015) and 14% higher levels of CD4 cells
(p = 0.038). In conclusion, polymorphisms in genes associated to the development of atherogenic
dyslipidemia, especially variants in APOA5 gene (rs3135506 and rs662799), can influence the circulating
CD4 T-cell levels in chronically HIV-infected patients. These data support previous reports on the effect of
lipid metabolism on immunologic parameters in HIV+ individuals on antiretroviral therapy.^^^^
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(c) 2015 Elsevier. Published article is available at: http://dx.doi.org/10.1016/j.antiviral.2014.12.002
Citació Bibliogràfica:
Echeverria, P., Guardiola, M., González, M., Vallvé, J. C., Bonjoch, A., Puig, J., et al. (2015). Association between polymorphisms in genes involved in lipid metabolism and immunological status in chronically HIV-infected patients. Antiviral Research, 114, 48-52.