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Association between polymorphisms in genes involved in lipid metabolism and immunological status in chronically HIV-infected patients

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dc.contributor Universitat de Vic - Universitat Central de Catalunya. Càtedra de la Sida i Malalties Relacionades
dc.contributor.author Echeverria, Patricia
dc.contributor.author Guardiola, M.
dc.contributor.author González, Marta
dc.contributor.author Vallvé, Joan Carles
dc.contributor.author Bonjoch, Anna
dc.contributor.author Puig, Jordi
dc.contributor.author Clotet, Bonaventura
dc.contributor.author Ribalta, J.
dc.contributor.author Negredo, Eugenia
dc.date.accessioned 2015-03-04T12:41:59Z
dc.date.available 2015-03-04T12:41:59Z
dc.date.created 2015
dc.date.issued 2015
dc.identifier.citation Echeverria, P., Guardiola, M., González, M., Vallvé, J. C., Bonjoch, A., Puig, J., et al. (2015). Association between polymorphisms in genes involved in lipid metabolism and immunological status in chronically HIV-infected patients. Antiviral Research, 114, 48-52. ca_ES
dc.identifier.issn 0166-3542
dc.identifier.uri http://hdl.handle.net/10854/3918
dc.description.abstract Several studies have reported associations between lipid parameters and clinical progression of HIV infection. We performed a cross-sectional study including 468 antiretroviral-treated HIV-infected patients to investigate the impact of 13 polymorphisms of 9 genes affecting lipid metabolism and CD4 and CD8-T cell levels. Polymorphisms were identified in genes selected for their role in the development of atherogenic dyslipidemia, defined as triglycerides P1.7 mmol/L and high-density lipoprotein cholesterol (HDLc) <1.02 in women or 1.28 mmol/L in men. Lipid and lipoprotein parameters were determined in all participants, as well as CD4 and CD8 T-cell counts. ANOVA was performed to compare the mean values of lipid and CD4 and CD8 T-cell count data. A Bonferroni correction for multiple comparisons was applied. 468 patients were included, 148 of them had a diagnosis of atherogenic dyslipidemia. The polymorphism rs3135506 in APOA5 was associated with a 9% increase in triglycerides (p = 0.002), 10% and 21% decrease in HDLc (p = 0.005), and CD4 T-cell count (p = 0.024), respectively. APOA5 rs662799, was associated with a 19% increase in CD8 T-cell count (p = 0.002). Carriers of LPL rs328 in the dyslipidemic group presented 11% higher levels of HDLc (p = 0.015) and 14% higher levels of CD4 cells (p = 0.038). In conclusion, polymorphisms in genes associated to the development of atherogenic dyslipidemia, especially variants in APOA5 gene (rs3135506 and rs662799), can influence the circulating CD4 T-cell levels in chronically HIV-infected patients. These data support previous reports on the effect of lipid metabolism on immunologic parameters in HIV+ individuals on antiretroviral therapy. en
dc.format application/pdf
dc.format.extent 5 p. ca_ES
dc.language.iso eng ca_ES
dc.publisher Elsevier ca_ES
dc.rights (c) 2015 Elsevier. Published article is available at: http://dx.doi.org/10.1016/j.antiviral.2014.12.002 ca_ES
dc.subject.other Sida -- Tractament ca_ES
dc.title Association between polymorphisms in genes involved in lipid metabolism and immunological status in chronically HIV-infected patients en
dc.type info:eu-repo/semantics/article ca_ES
dc.identifier.doi https://doi.org/10.1016/j.antiviral.2014.12.002
dc.rights.accesRights info:eu-repo/semantics/closedAccess ca_ES
dc.type.version info:eu-repo/publishedVersion ca_ES
dc.indexacio Indexat a SCOPUS ca_ES

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