Gastric cancer and gastro-oesophageal junction cancer represent
a global health-care challenge. Despite the efficacy of improved
chemotherapy and surgical options, these patients still have a poor
prognosis. In advanced disease, only trastuzumab and some immune
checkpoint inhibitors, such as nivolumab and pembrolizumab ...»»»»
Gastric cancer and gastro-oesophageal junction cancer represent
a global health-care challenge. Despite the efficacy of improved
chemotherapy and surgical options, these patients still have a poor
prognosis. In advanced disease, only trastuzumab and some immune
checkpoint inhibitors, such as nivolumab and pembrolizumab in
addition to chemotherapy, have demonstrated consistent and reliable
efficacy in patients with HER2-positive and PDL1-positive tumours,
respectively. In this Review, we discuss the intrinsic characteristics
of gastric and gastro-oesophageal cancer from the molecular and
clinical perspectives and provide a comprehensive review of previously
reported and ongoing phase II and III clinical trials with targeted agents
and immunotherapy in advanced and localized settings. Finally, we
suggest alternative strategies to help overcome current challenges in
precision medicine and to improve outcomes for these patients.^^^^
Tipus:
Article
Indexació:
Indexat a WOS/JCR
Indexat a SCOPUS
Drets:
Tots els drets reservats
Citació Bibliogràfica:
Alsina, M., Arrazubi, V., Diez, M. et al. Current developments in gastric cancer: from molecular profiling to treatment strategy. Nat Rev Gastroenterol Hepatol 20, 155–170 (2023). https://doi.org/10.1038/s41575-022-00703-w