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Evolution of mtDNA variation during canid’s domestication

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dc.contributor Universitat de Vic - Universitat Central de Catalunya. Facultat de Ciències i Tecnologia
dc.contributor Universitat de Vic - Universitat Central de Catalunya. Màster Universitari en Anàlisi de Dades Òmiques
dc.contributor.author González Basallote, Víctor Manuel
dc.date.accessioned 2018-02-08T18:28:47Z
dc.date.available 2018-02-08T18:28:47Z
dc.date.created 2017-09-18
dc.date.issued 2017-09-18
dc.identifier.uri http://hdl.handle.net/10854/5319
dc.description.abstract The close coexistence between human beings and dogs and the efficiency in their domestication have made dogs a very interesting target for basic research. By studying the history and evolution of dogs, much can be learned about human health, history and social behavior. Moreover, dogs show some astounding diversity patterns which make them mystifyingly unique; to date, no other species has ever been found to spawn such a huge morphological variability (dog breeds) from a very little initial effective population size in a very short period of time. In this project, we have put all our efforts into two noteworthy aspects. First, we completely redesigned an in-house mitochondrial DNA reconstruction pipeline which, after having assessed its efficiency and performance, we used it to reconstruct a large dataset containing almost all the available dog breeds and well as other samples from different canids. Then, the reconstructed sequences were used to study crucial aspects of dog evolution: A massive scale phylogeny was built to see whether the current morphology-based classification of dogs truly correlates with their genetic distances as well as other aspects. In addition to that, we have inferred the population history of dogs, which showed a population bottleneck and posterior expansion attributable to a domestication event, and we got results about the Time to the Most Common Ancestors (TMRCAs) between divergent species. Furthermore, we assessed some evolutionary statistics which showed the strong purifying selection acting on canids, but also that dogs could have a relaxation in this selection due to the artificial breeding and selection made by humans. Finally yet importantly, we encountered a discrepancy in the starting codon of the ND4L gene in the reference genome of dogs (CanFam 3.1.) which suggest that the gene does not start in the proposed codon but in a nearby one. Key words: bioinformatics, mtArchitect, dogs, canids, wolves, phylogenesis, mitochondrial DNA. es
dc.format.extent 60 p. es
dc.language.iso eng es
dc.rights Tots els drets reservats es
dc.subject.other Bioinformàtica es
dc.subject.other Gossos es
dc.subject.other Cànids es
dc.subject.other Llops es
dc.subject.other Filogènia es
dc.subject.other ADN mitocondrial es
dc.title Evolution of mtDNA variation during canid’s domestication es
dc.type info:eu-repo/semantics/masterThesis es
dc.description.version Director: Tomàs Marquès-Bonet Co-director: Narcis Fernández Fuentes
dc.rights.accesRights info:eu-repo/semantics/openAccess es

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