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Increased ex vivo cell death of central memory CD4 T cells in treated HIV infected individuals with unsatisfactory immune recovery

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dc.contributor Universitat de Vic - Universitat Central de Catalunya. Càtedra de la Sida i Malalties Relacionades
dc.contributor.author Massanella, Marta
dc.contributor.author Gómez-Mora, Elisabet
dc.contributor.author Carrillo, Jorge
dc.contributor.author Curriu, Marta
dc.contributor.author Ouchi, Dan
dc.contributor.author Puig, Jordi
dc.contributor.author Negredo, Eugenia
dc.contributor.author Cabrera, Cecilia
dc.contributor.author Clotet, Bonaventura
dc.contributor.author Blanco, Julià
dc.date.accessioned 2015-09-17T09:53:18Z
dc.date.available 2015-09-17T09:53:18Z
dc.date.issued 2015
dc.identifier.citation Massanella, M., Gómez-Mora, E., Carrillo, J., Curriu, M., Ouchi, D., Puig, J., et al. (2015). Increased ex vivo cell death of central memory CD4 T cells in treated HIV infected individuals with unsatisfactory immune recovery. Journal of Translational Medicine, 13(1) ca_ES
dc.identifier.issn 14795876
dc.identifier.uri http://hdl.handle.net/10854/4171
dc.description.abstract Abstract Background: High levels of ex vivo CD4 T-cell death and the accumulation of highly differentiated and/or immunosenescent T cells have been associated with poor CD4 T-cell recovery in treated HIV-infected individuals. However, the relationship between cell death and T-cell differentiation is still unclear. Methods: We have analyzed cell death, immunosenescence and differentiation parameters in HAART-treated subjects (VL <50 copies/mL for more than 2 years) with CD4 T-cell count <350 cells/μL (immunodiscordant, n = 23) or >400 cells/μL (immunoconcordant, n = 33). We included 11 healthy individuals as reference. Results: As expected, suboptimal CD4 T-cell recovery was associated with low frequencies of naïve cells, high frequencies of transitional and effector memory cells and a subsequent low ratio of central/transitional memory cells in the CD4 compartment. These alterations correlated with spontaneous CD4 T-cell death. A deeper analysis of cell death in CD4 T-cell subsets showed increased cell death in memory cells of immunodiscordant individuals, mainly affecting central memory cells. Immunosenescence was also higher in immunodiscordant individuals albeit unrelated to cell death. The CD8 compartment was similar in both HIV-infected groups, except for an underrepresentation of naïve cells in immunodiscordant individuals. Conclusion: Immunodiscordant individuals show alterations in memory CD4 T-cell differentiation associated with a short ex vivo lifespan of central memory cells and an in vivo low central/transitional memory cell ratio. These alterations may contribute to poor CD4 T-cell repopulation. Keywords: Immunodiscordant, Cell death, T-cell subsets, Immunosenescence, HAART, cART ca_ES
dc.format application/pdf
dc.format.extent 11 p. ca_ES
dc.language.iso eng ca_ES
dc.publisher Biomed central ca_ES
dc.rights Aquest document està subjecte a aquesta llicència Creative Commons ca_ES
dc.rights.uri http://creativecommons.org/licenses/by-nc/3.0/es/ ca_ES
dc.subject.other Sida -- Tractament ca_ES
dc.title Increased ex vivo cell death of central memory CD4 T cells in treated HIV infected individuals with unsatisfactory immune recovery ca_ES
dc.type info:eu-repo/semantics/article ca_ES
dc.identifier.doi https://doi.org/10.1186/s12967-015-0601-2
dc.rights.accesRights info:eu-repo/semantics/openAccess ca_ES
dc.type.version info:eu-repo/publishedVersion ca_ES
dc.indexacio Indexat a WOS/JCR ca_ES
dc.indexacio Indexat a SCOPUS

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