Registro sencillo
dc.contributor |
Universitat de Vic - Universitat Central de Catalunya. Càtedra de la Sida i Malalties Relacionades |
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dc.contributor.author |
Pino, Maria
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dc.contributor.author |
Erkizia, Itziar
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dc.contributor.author |
Benet, Susana
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dc.contributor.author |
Erikson, Elina
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dc.contributor.author |
Fernández Figueras, María Teresa
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dc.contributor.author |
Guerrero, Dolores
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Dalmau, Judith
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dc.contributor.author |
Ouchi, Dan
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dc.contributor.author |
Rausell, Antonio
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dc.contributor.author |
Ciuffi, Angela
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dc.contributor.author |
Keppler, Oliver T.
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Telenti, Amalio
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Kräusslich, H.G.
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Martinez Picado, Francisco Javier
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Izquierdo Useros, Nuria
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dc.date.accessioned |
2015-05-18T08:02:59Z |
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dc.date.available |
2015-05-18T08:02:59Z |
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dc.date.created |
2015 |
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dc.date.issued |
2015 |
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dc.identifier.citation |
Pino, M., Erkizia, I., Benet, S., Erikson, E., Fernández-Figueras, M. T., Guerrero, D., et al. (2015). HIV-1 immune activation induces siglec-1 expression and enhances viral trans-infection in blood and tissue myeloid cells. Retrovirology, 12(1) |
ca_ES |
dc.identifier.issn |
1742-4690 |
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dc.identifier.uri |
http://hdl.handle.net/10854/4048 |
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dc.description.abstract |
Background: Myeloid cells are key players in the recognition and response of the host against invading viruses.
Paradoxically, upon HIV-1 infection, myeloid cells might also promote viral pathogenesis through trans-infection, a
mechanism that promotes HIV-1 transmission to target cells via viral capture and storage. The receptor Siglec-1
(CD169) potently enhances HIV-1 trans-infection and is regulated by immune activating signals present throughout
the course of HIV-1 infection, such as interferon α (IFNα).
Results: Here we show that IFNα-activated dendritic cells, monocytes and macrophages have an enhanced ability
to capture and trans-infect HIV-1 via Siglec-1 recognition of viral membrane gangliosides. Monocytes from untreated
HIV-1-infected individuals trans-infect HIV-1 via Siglec-1, but this capacity diminishes after effective antiretroviral
treatment. Furthermore, Siglec-1 is expressed on myeloid cells residing in lymphoid tissues, where it can mediate
viral trans-infection.
Conclusions: Siglec-1 on myeloid cells could fuel novel CD4+ T-cell infections and contribute to HIV-1 dissemination
in vivo. |
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dc.format |
application/pdf |
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dc.format.extent |
15 p. |
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dc.language.iso |
eng |
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dc.publisher |
BioMed Central |
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dc.rights |
Aquest document està subjecte a aquesta llicència Creative Commons |
ca_ES |
dc.rights.uri |
http://creativecommons.org/licenses/by/3.0/es/ |
ca_ES |
dc.subject.other |
Sida -- Tractament |
ca_ES |
dc.subject.other |
VIH (Virus) |
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dc.title |
HIV-1 immune activation induces siglec-1 expression and enhances viral trans-infection in blood and tissue myeloid cells |
ca_ES |
dc.type |
info:eu-repo/semantics/article |
ca_ES |
dc.identifier.doi |
https://doi.org/10.1186/s12977-015-0160-x |
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dc.rights.accessRights |
info:eu-repo/semantics/openAccess |
ca_ES |
dc.type.version |
info:eu-repo/publishedVersion |
ca_ES |
dc.indexacio |
Indexat a SCOPUS |
ca_ES |
dc.indexacio |
Indexat a WOS/JCR |
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