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Effect of lithium on HIV-1 expression and proviral reservoir size in the CD4R T cells of antiretroviral therapy suppressed patients

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dc.contributor Universitat de Vic - Universitat Central de Catalunya. Càtedra de la Sida i Malalties Relacionades
dc.contributor.author Puertas, M.C.
dc.contributor.author Salgado, Maria
dc.contributor.author Morón López, Sara
dc.contributor.author Ouchi, Dan
dc.contributor.author Muñoz-Moreno, José A.
dc.contributor.author Clotet, Bonaventura
dc.contributor.author Martinez Picado, Francisco Javier
dc.date.accessioned 2014-09-17T09:57:17Z
dc.date.available 2014-09-17T09:57:17Z
dc.date.created 2014
dc.date.issued 2014
dc.identifier.citation Puertas, M. C., Salgado, M., López, S. M., Ouchi, D., Muñoz-Moreno, J. A., Moltó, J., et al. (2014). Effect of lithium on HIV-1 expression and proviral reservoir size in the CD4+ T cells of antiretroviral therapy suppressed patients. Aids, 28(14), 2157-2159. 10.1097/QAD.0000000000000373 ca_ES
dc.identifier.issn 0269-9370
dc.identifier.uri http://hdl.handle.net/10854/3265
dc.description.abstract Previous in-vitro data pointed out lithium, an activator of the b-catenin signalling pathway, as a modulator of HIV-1 transcription. We assessed the effect of in-vivo administration of lithium on viral latency modulation in nine antiretroviral therapy (ART)-suppressed HIV-1-infected individuals. We found that lithium carbonate treatment was able to transiently repress HIV-1 residual expression in CD4R T cells in vivo, which led to a concomitant short-term decrease in the proviral reservoir size. en
dc.format application/pdf
dc.format.extent 10 p. ca_ES
dc.language.iso eng ca_ES
dc.publisher Lippincott Williams & Wilkins ca_ES
dc.rights (c) Lippincott Williams & Wilkins
dc.rights Tots els drets reservats ca_ES
dc.subject.other Sida -- Tractament ca_ES
dc.title Effect of lithium on HIV-1 expression and proviral reservoir size in the CD4R T cells of antiretroviral therapy suppressed patients en
dc.type info:eu-repo/semantics/article ca_ES
dc.identifier.doi https://doi.org/10.1097/QAD.0000000000000373
dc.relation.publisherversion http://journals.lww.com/aidsonline/Abstract/2014/09100/HIV_2_X4_tropism_is_associated_with_lower_CD4_.18.aspx
dc.rights.accesRights info:eu-repo/semantics/closedAccess ca_ES
dc.type.version info:eu-repo/publishedVersion ca_ES
dc.indexacio Indexat a WOS/JCR
dc.indexacio Indexat a SCOPUS ca_ES

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