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HIV-1 Capture and Transmission by Dendritic Cells: The Role of Viral Glycolipids and the Cellular Receptor Siglec-1

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dc.contributor Universitat de Vic - Universitat Central de Catalunya. Càtedra de la Sida i Malalties Relacionades
dc.contributor.author Izquierdo Useros, Nuria
dc.contributor.author Lorizate, M.
dc.contributor.author McLaren, P.J.
dc.contributor.author Telenti, Amalio
dc.contributor.author Kräusslich, H.G.
dc.contributor.author Martinez Picado, Francisco Javier
dc.date.accessioned 2014-09-16T15:53:53Z
dc.date.available 2014-09-16T15:53:53Z
dc.date.issued 2014
dc.identifier.citation Izquierdo-Useros, N., Lorizate, M., McLaren, P. J., Telenti, A., Kräusslich, H. -., & Martínez-Picado, J. (2014). HIV-1 capture and transmission by dendritic cells: The role of viral glycolipids and the cellular receptor siglec-1. PLoS Pathogens, 10(7). 10.1371/journal.ppat.1004146 ca_ES
dc.identifier.issn 1553-7374
dc.identifier.uri http://hdl.handle.net/10854/3258
dc.description.abstract Dendritic cells (DCs) are essential in order to combat invading viruses and trigger antiviral responses. Paradoxically, in the case of HIV-1, DCs might contribute to viral pathogenesis through trans-infection, a mechanism that promotes viral capture and transmission to target cells, especially after DC maturation. In this review, we highlight recent evidence identifying sialyllactosecontaining gangliosides in the viral membrane and the cellular lectin Siglec-1 as critical determinants for HIV-1 capture and storage by mature DCs and for DC-mediated trans-infection of T cells. In contrast, DC-SIGN, long considered to be the main receptor for DC capture of HIV-1, plays a minor role in mature DC-mediated HIV-1 capture and trans-infection. ca_ES
dc.format application/pdf
dc.format.extent 9 p. ca_ES
dc.language.iso eng ca_ES
dc.publisher Public Library of Science ca_ES
dc.rights Aquest document està subjecte a aquesta llicència Creative Commons ca_ES
dc.rights.uri http://creativecommons.org/licenses/by/3.0/es/ ca_ES
dc.subject.other Sida -- Tractament ca_ES
dc.title HIV-1 Capture and Transmission by Dendritic Cells: The Role of Viral Glycolipids and the Cellular Receptor Siglec-1 ca_ES
dc.type info:eu-repo/semantics/article ca_ES
dc.identifier.doi https://doi.org/10.1371/journal.ppat.1004146
dc.relation.publisherversion http://www.plospathogens.org/article/authors/info%3Adoi%2F10.1371%2Fjournal.ppat.1004146
dc.relation.publisherversion
dc.rights.accesRights info:eu-repo/semantics/openAccess ca_ES
dc.type.version info:eu-repo/acceptedVersion ca_ES
dc.indexacio Indexat a SCOPUS
dc.indexacio Indexat a WOS/JCR ca_ES

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