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Browsing Articles by Author "Villà-Freixa, Jordi"

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Chromatin-Bound IkBa Regulates a Subset of Polycomb Target Genes in Differentiation and Cancer

Mulero, María Carmen; Ferres-Marco, Dolors; Islam, Abul; Margalef, Pol; Pecoraro, Matteo; Toll, Agustí; Drechsel, Nils; Charneco, Cristina; Davies, Shelly; Bellora, Nicolás; Gallardo, Fernando; López-Arribillaga, Erika; Asensio-Juan, Elena; Rodilla, Verónica; González, Jessica; Iglesias, Mar; Shih, Vincent; Albà, M. Mar; Di Croce, Luciano; Hoffmann, Alexander; Miyamoto, Shigeki; Villà-Freixa, Jordi; López Bigas, Núria; Keyes, William M.; Domínguez, María; Bigas, Anna; Espinosa, Lluís (Elsevier, 2013)

IkB proteins are the primary inhibitors of NF-kB. Here, we demonstrate that sumoylated and phosphorylated IkBa accumulates in the nucleus of keratinocytes and interacts with histones H2A and H4 at the regulatory region ...
Computational exploration of the binding mode of heme-dependent stimulators into the active catalytic domain of soluble guanylate cyclase.

Agulló, Luis; Gutiérrez de Teran, H.; Garcia-Dorado, D.; Villà-Freixa, Jordi; Buch, Ignasi (Wiley Periodicals, 10-2016)

Soluble guanylate cyclase (sGC), the main target of nitric oxide (NO), has been proven to have a significant role in coronary artery disease, pulmonary hypertension, erectile dysfunction, and myocardial infarction. One of ...
Methylglyoxal Produced by Amyloid- Peptide-Induced Nitrotyrosination of Triosephosphate Isomerase Triggers Neuronal Death in Alzheimer’s Disease

Tajes, M.; Eraso-Pichot, A.; Rubio-Moscardó, F.; Guivernau, B.; Ramos-Fernández, E.; Bosch-Morató, M.; Guix, F.X.; Clarimón, J.; Miscione, G.P.; Boada, M.; Gil-Gómez, G.; Suzuki, T.; Molina, H.; Villà-Freixa, Jordi; Vicente, R.; Muñoz Silva, Fernando (IOP Press, 2014)

Amyloid-β peptide (Aβ) aggregates induce nitro-oxidative stress, contributing to the characteristic neurodegeneration found in Alzheimer's disease (AD). One of the most strongly nitrotyrosinated proteins in AD is the ...
New Model of Cystic Fibrosis Transmembrane Conductance Regulator Proposes Active Channel-like Conformation

Dalton, James; Kalid, Ori; Schushan, Maya; Ben-Tal, Nir; Villà-Freixa, Jordi (American Chemical Society, 2012)

The cystic fibrosis transmembrane conductance regulator (CFTR) is an unusual ABC transporter, functioning as a chloride channel critical for fluid homeostasis in multiple organs. Disruption of CFTR function is associated ...
Proteoliposomal formulations of an HIV-1 gp41-based miniprotein elicit a lipid-dependent immunodominant response overlapping the 2F5 binding motif

Molinos-Albert, Luis M.; Bilbao, Eneritz; Agulló, Luis; Marfil, Sílvia; García, Elisabet; Rodríguez de la Concepción, Maria L.; Izquierdo Useros, Nuria; Vilaplana, Cristina; Nieto-Garai, Jon A.; Contreras, F. Xabier; Floor Pilquil, Martin Luciano; Cardona, Pere J.; Martinez Picado, Francisco Javier; Clotet, Bonaventura; Villà-Freixa, Jordi; Lorizate, M.; Carrillo, Jorge; Blanco, Julià (Nature Publishing Group, 2017)

The HIV-1 gp41 Membrane Proximal External Region (MPER) is recognized by broadly neutralizing antibodies and represents a promising vaccine target. However, MPER immunogenicity and antibody activity are influenced by ...
TRIFORCE: Tessellated semianalytical solvent exposed surface areas and derivatives

Drechsel, Nils; Fennell, C.J.; Dill, K.A.; Villà-Freixa, Jordi (American Chemical Society, 2014)

We present a new approach to the calculation of solvent-accessible surface areas of molecules with potential application to surface area based methods for determination of solvation free energies. As in traditional ...

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