Background: Research in epistasis or gene-gene interaction detection for human complex traits has grown over the last few years. It has been marked by promising methodological developments, improved translation efforts ...

The analysis of gene interactions and epistatic patterns of susceptibility is especially important for investigating complex diseases such as cancer characterized by the joint action of several genes. This work is motivated ...

Summary: We describe mbmdr, an R package for implementing the model-based multifactor dimensionality reduction (MB-MDR) method. MB-MDR has been proposed by Calle et al. as a dimension reduction method for exploring ...

L'objectiu de l'epidemiologia genètica és comprendre els efectes dels gens i els factors ambientals en la salut humana. Un aspecte important és l’estudi del paper de la variabilitat genètica en el risc de malalties comunes ...