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Investigation of the Genomic Landscape of Linker Histone 1 Subtypes Uncovers Differences among Variants and a Potential Dual Behaviour of H1X Subtype in Human Cervical Cancer Cells

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dc.contributor Universitat de Vic - Universitat Central de Catalunya. Facultat de Ciències i Tecnologia
dc.contributor Universitat de Vic - Universitat Central de Catalunya. Màster Universitari en Anàlisi de Dades Òmiques
dc.contributor.author López Anguita, Natalia
dc.date.accessioned 2019-04-09T10:28:50Z
dc.date.available 2019-04-09T10:28:50Z
dc.date.created 2018-09-16
dc.date.issued 2018-09-16
dc.identifier.uri http://hdl.handle.net/10854/5770
dc.description Curs 2017-2018 es
dc.description.abstract Human cells contain seven somatic histone H1 variants (H1.1 to H1.5, H1.0 and H1X). Although some advances have been recently achieved in the understanding of the H1 subtypes genomic distribution, whether they present specific functions or they do have redundant roles still remains elusive, as the possibility of H1 variants having distinct roles in a cell-specific manner. Here, we map the genomic localization of several H1 variants in cervical cancer cells, specifically HeLa-S3 cell line by using chromatin immunoprecipitation followed by massively parallel sequencing (ChIP-seq) in wild type and HA-tagged engineered cell lines. In short, our work integrates the genomic distribution at promoters, genome-wide and important genomic features. In addition, we present a cytogenetic band classification model by which we prove variant-specific location as well as new insights about the potential dual behaviour of H1X variant along the genome. es
dc.format application/pdf es
dc.format.extent 38 p. es
dc.language.iso eng es
dc.rights Tots els drets reservats es
dc.subject.other Genoma humà es
dc.subject.other Coll -- Malalties es
dc.subject.other Cèl·lules canceroses es
dc.subject.other Histones es
dc.title Investigation of the Genomic Landscape of Linker Histone 1 Subtypes Uncovers Differences among Variants and a Potential Dual Behaviour of H1X Subtype in Human Cervical Cancer Cells es
dc.type info:eu-repo/semantics/masterThesis es
dc.rights.accesRights info:eu-repo/semantics/closedAccess es

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