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Methylation Data Analysis Associated with Alzheimer’s Disease

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dc.contributor Universitat de Vic - Universitat Central de Catalunya. Facultat de Ciències i Tecnologia
dc.contributor Universitat de Vic - Universitat Central de Catalunya. Màster Universitari en Anàlisi de Dades Òmiques
dc.contributor.author Mosquera, José Luis
dc.date.accessioned 2016-03-03T10:59:04Z
dc.date.available 2016-03-03T10:59:04Z
dc.date.created 2015-09
dc.date.issued 2015-09
dc.identifier.uri http://hdl.handle.net/10854/4445
dc.description Curs 2014-2015 ca_ES
dc.description.abstract Alzheimer disease (AD) is associated with distinctive changes in DNA methylation patterns. DNA methylation is a chemical modification that is involved in gene silencing. These modifications give rise to heritable changes in gene expression without altering the DNA sequence. In a first study, researchers observed differential methylated regions (DMRs) in a specific DNA in postmortem brains from AD patients. Due to this fact we decided to focus on two target genes from AD in order to compare differences in methylation between different experimental situations. In this project, we have developed a pipeline for finding DMR between different experimental conditions based on methylation data generated with the 454 GS FLX system from Roche, and DNA bisulfite-treated samples. ca_ES
dc.format application/pdf
dc.format.extent 62 p. ca_ES
dc.language.iso eng ca_ES
dc.rights Aquest document està subjecte a aquesta llicència Creative Commons ca_ES
dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/3.0/es/ ca_ES
dc.subject.other Alzheimer, Malaltia d' ca_ES
dc.subject.other ADN ca_ES
dc.title Methylation Data Analysis Associated with Alzheimer’s Disease ca_ES
dc.type info:eu-repo/semantics/masterThesis ca_ES
dc.description.version Director/a: Malu Calle, co-director: Marta Barrachina Castillo
dc.rights.accesRights info:eu-repo/semantics/openAccess ca_ES

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