DSpace Repository

Immune Screening Identifies Novel T Cell Targets Encoded by Antisense Reading Frames of HIV-1

Immune Screening Identifies Novel T Cell Targets Encoded by Antisense Reading Frames of HIV-1
 
Berger, Christoph T. ; Llano, Anuska ; Carlson, Jonathan M. ; Brumme, Zabrina L. ; Brockman, Mark A. ; Cedeño, Samandhy ; Harrigan, R. ; Kaufmann, Daniel E. ; Heckerman, David ; Meyerhans, Andreas ; Brander, Christian
2015

Files in this item

Icon
Name: artconlli_a2015_berger_christoph_immune_screening.pdf
Size: 1.287Mb
Format: PDF
Enllaç permanent: http://hdl.handle.net/10854/4320
 
Versió de l'editor: https://doi.org/10.1186/s12967-015-0392-5
 

Abstract

Cytotoxic-T lymphocyte (CTL) responses to epitopes in alternative HIV reading frames have been reported. However, the extent of CTL responses to putative proteins encoded in antisense reading frames is unknown. Using sequence alignments and computational approaches, we here predict five potential antisense HIV proteins and ...»»»»
Cytotoxic-T lymphocyte (CTL) responses to epitopes in alternative HIV reading frames have been reported. However, the extent of CTL responses to putative proteins encoded in antisense reading frames is unknown. Using sequence alignments and computational approaches, we here predict five potential antisense HIV proteins and characterize common CTL responses against them. Results suggest that antisense-derived sequences are commonly transcribed and translated and could encode functional proteins that contain important targets of anti-HIV cellular immunity.^^^^

Type:

Article

xmlui.dri2xhtml.METS-1.0.item-indexacio:

 
Indexat a WOS/JCR
 
Indexat a SCOPUS
 

Rights:

 
Tots els drets reservats
 
(c) American Society for Microbiology
 

Citation:

Berger, C. T., Llano, A., Carlson, J. M., Brumme, Z. L., Brockman, M. A., Cedeño, S., et al. (2015). Immune screening identifies novel T cell targets encoded by antisense reading frames of HIV-1. Journal of Virology, 89(7), 4015-4019.