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Alternative Effector-Function Profiling Identifies Broad HIV-Specific T-Cell Responses in Highly HIV-Exposed Individuals Who Remain Uninfected

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dc.contributor Universitat de Vic. Càtedra de la Sida i Malalties Relacionades
dc.contributor.author Ruiz-Riol, Marta
dc.contributor.author Llano, Anuska
dc.contributor.author Ibarrondo, Javier
dc.contributor.author Zamarreño, Jennifer
dc.contributor.author Yusim, Karina
dc.contributor.author Back, Vanessa
dc.contributor.author Mothe, B.
dc.contributor.author Pérez-Alvarez, Susana
dc.contributor.author Fernández, M.A.
dc.contributor.author Requena, Gerard
dc.contributor.author Meulbroek, Michael
dc.contributor.author Pujol, Ferran
dc.contributor.author Leon, Agathe
dc.contributor.author Cobarsi, P.
dc.contributor.author Korber, Bette T.
dc.contributor.author Clotet, Bonaventura
dc.contributor.author Ganoza, C.
dc.contributor.author Sánchez, Jorge
dc.contributor.author Coll, J.
dc.contributor.author Brander, Christian
dc.date.accessioned 2015-03-20T10:41:53Z
dc.date.available 2015-03-20T10:41:53Z
dc.date.created 2015
dc.date.issued 2015
dc.identifier.citation Ruiz-Riol, M., Llano, A., Ibarrondo, J., Zamarreño, J., Yusim, K., Bach, V., et al. (2015). Alternative effector-function profiling identifies broad HIV-specific T-cell responses in highly HIV-exposed individuals who remain uninfected. Journal of Infectious Diseases, 211(6), 936-946. ca_ES
dc.identifier.issn 0022-1899
dc.identifier.uri http://hdl.handle.net/10854/3940
dc.description.abstract The characterization of host immune responses to human immunodeficiency virus (HIV) in HIV controllers and individuals with high exposure but seronegativity to HIV (HESN) is needed to guide the development of effective preventive and therapeutic vaccine candidates. However, several technical hurdles severely limit the definition of an effective virus-specific T-cell response. By using a toggle-peptide approach, which takes HIV sequence diversity into account, and a novel, boosted cytokine staining/flow cytometry strategy, we here describe new patterns of T-cell responses to HIV that would be missed by standard assays. Importantly, this approach also allows detection of broad and strong virus-specific T-cell responses in HESN individuals that are characterized by a T-helper type 1 cytokine–like effector profile and produce cytokines that have been associated with potential control of HIV infection, including interleukin 10, interleukin 13, and interleukin 22. These results establish a novel approach to improve the current understanding of HIV-specific T-cell immunity and identify cellular immune responses and individual cytokines as potential markers of relative HIV resistance. As such, the findings also help develop similar strategies for more-comprehensive assessments of host immune responses to other human infections and immune-mediated disorders. en
dc.format application/pdf
dc.format.extent 10 p. ca_ES
dc.language.iso eng ca_ES
dc.publisher Oxford University Press ca_ES
dc.rights (c) Oxford University Press
dc.rights Tots els drets reservats ca_ES
dc.subject.other Sida -- Tractament ca_ES
dc.title Alternative Effector-Function Profiling Identifies Broad HIV-Specific T-Cell Responses in Highly HIV-Exposed Individuals Who Remain Uninfected en
dc.type info:eu-repo/semantics/article ca_ES
dc.identifier.doi https://doi.org/10.1093/infdis/jiu534
dc.rights.accesRights info:eu-repo/semantics/closedAccess ca_ES
dc.type.version info:eu-repo/publishedVersion ca_ES
dc.indexacio Indexat a SCOPUS ca_ES
dc.indexacio Indexat a WOS/JCR

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