dc.contributor |
Universitat de Vic. Càtedra de la Sida i Malalties Relacionades |
|
dc.contributor.author |
Podzamczer Palter, Daniel |
|
dc.contributor.author |
Imaz, A. |
|
dc.contributor.author |
Pérez, I. |
|
dc.contributor.author |
Viciana, P. |
|
dc.contributor.author |
Valencia, E. |
|
dc.contributor.author |
Curto, J. |
|
dc.contributor.author |
Martín, T. |
|
dc.contributor.author |
Castaño, M. |
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dc.contributor.author |
Rojas, J. |
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dc.contributor.author |
Espinosa, N. |
|
dc.contributor.author |
Moreno, V. |
|
dc.contributor.author |
Asensi, V. |
|
dc.contributor.author |
Iribarren, José Antonio |
|
dc.contributor.author |
Clotet, Bonaventura |
|
dc.contributor.author |
Force, Lluis |
|
dc.contributor.author |
Bachiller, P. |
|
dc.contributor.author |
Knobel, Hernando |
|
dc.contributor.author |
López Bernaldo de Quirós, Juan Carlos |
|
dc.contributor.author |
Blanco, J.R. |
|
dc.contributor.author |
Rozas N. |
|
dc.contributor.author |
Vergas, J. |
|
dc.contributor.author |
Ocampo, A. |
|
dc.contributor.author |
Camacho, A. |
|
dc.contributor.author |
Flores, J. |
|
dc.contributor.author |
Gómez-Sirvent J.L. |
|
dc.date.accessioned |
2014-09-17T11:45:38Z |
|
dc.date.available |
2014-09-17T11:45:38Z |
|
dc.date.created |
2014 |
|
dc.date.issued |
2014 |
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dc.identifier.citation |
Podzamczer, D., Imaz, A., Perez, I., Viciana, P., Valencia, E., Curto, J., et al. (2014). Abacavir/lamivudine plus darunavir/ritonavir in routine clinical practice: A multicentre experience in antiretroviral therapy-naive and -experienced patients. Journal of Antimicrobial Chemotherapy, 69(9), pp. 2536-2540. 10.1093/jac/dku157 |
ca_ES |
dc.identifier.issn |
1460-2091 |
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dc.identifier.uri |
http://hdl.handle.net/10854/3268 |
|
dc.description.abstract |
Objectives: To present clinical experience with a regimen including abacavir/lamivudine+darunavir/ritonavir in a
cohort of HIV-1-infected patients.
Methods: A retrospective, multicentre cohort study, including all consecutive adult HIV-1-infected patients who
started abacavir/lamivudine+darunavir/ritonavir from April 2008 to December 2010 and had at least one followup
visit. The primary endpoint was HIV-1 viral load (VL) ,40 copies/mL at week 48.
Results: One hundred and eighty-three patients (42 naive and 141 experienced) from 19 hospitals in Spain were
studied. The median follow-up was 26.7 (0.5–58.6) months, 79.8% were men, the median age was 47.1 (21.4–
80.5) years, 26.2% had AIDS and 38.8% were positive for hepatitis C virus. At baseline, the median CD4 count was
246 cells/mm3 in naive patients and 393 cells/mm3 in experienced patients and the median VL was 4.80 and
,1.59 log copies/mL, respectively. Atweek 48, 81.8% of naive patients and 84.2% of experienced patients receiving
the regimen reached a VL ,40 copies/mL, whereas at 96 weeks this occurred in 90.5% and 92.8%, respectively.
CD4 cell count increases at 48 and 96 weeks were +176.5 and +283.5 cells/mm3 in naive patients and
+74.9 and +93 cells/mm3 in experienced patients, respectively. Overall, 86 (47%) patients discontinued the
study regimen, in many cases possibly related to non-medical reasons, such as drug switches to reduce cost
or changes in address due to economic constraints. Three patients died of causes unrelated to therapy and 19
(10.4%) discontinued the regimen due to adverse events.
Conclusions: In our cohort, abacavir/lamivudine+darunavir/ritonavir was safe, well tolerated and achieved high
rates of virological suppression. In a proportion of patients, discontinuation of this effective regimen was possibly
due to non-medical reasons. |
en |
dc.format |
application/pdf |
|
dc.format.extent |
5 p. |
ca_ES |
dc.language.iso |
eng |
ca_ES |
dc.publisher |
Oxford University Press |
ca_ES |
dc.rights |
(c) Oxford University Press |
|
dc.rights |
Tots els drets reservats |
ca_ES |
dc.subject.other |
Sida -- Tractament |
ca_ES |
dc.title |
Abacavir/lamivudine plus darunavir/ritonavir in routine clinical practice: a multicentre experience in antiretroviral therapy-naive and -experienced patients |
en |
dc.type |
info:eu-repo/semantics/article |
ca_ES |
dc.identifier.doi |
https://doi.org/10.1093/jac/dku157 |
|
dc.relation.publisherversion |
http://jac.oxfordjournals.org/content/69/9/2536.abstract?sid=5e7cd1cd-69c9-4fb5-ad09-412c92c4a4d6 |
|
dc.rights.accessRights |
info:eu-repo/semantics/closedAccess |
ca_ES |
dc.type.version |
info:eu-repo/publishedVersion |
ca_ES |
dc.indexacio |
Indexat a WOS/JCR |
|
dc.indexacio |
Indexat a SCOPUS |
ca_ES |