The clinical application of T-cells genetically engineered to express a chimeric antigen receptor (CAR) targeting CD19 is challenged by CD19 negative relapse in B-cell acute lymphoblastic leukaemia (B-ALL). Dual (CD19 ...

The characterization of the small transcriptome reveals a generalized down-regulation both at premanifest and manifest stages, which brings out the course of Huntington’s disease. Partial Least Squares Discriminant Analysis ...

Single-cell RNA sequencing (scRNA-seq) is a powerful new method that makes it possible to study gene expression data at the level of individual cells. Cell type annotation, using a reference sets, is a crucial step in ...

Inversion polymorphisms is a mechanism that involves a change in the orientation of a DNA segment within a chromosome, but there is still a lack of their association with disease. However, recently developed computational ...

Motivation: The diversity and huge omics data take biology and biomedicine research and application into a big data era. Most of the current statistical analyses required to analyze omic data are not designed to deal ...

Traditionally, the detection and identification of microorganisms in water samples is done by culture-dependent methods, but these do not allow the detection of all microorganisms. High-throughput sequencing now makes ...

Codons as fragments of the genetic code articulate both nucleotidic and proteic constraints. If codon usage bias is now admitted to be mainly influenced by GC content, codon frequencies in general may display a more ...

Abstract Background: The emergence of deep learning (DL) in the field of medical imaging has brought significant improvements, especially in pathology and radiology. In pathology, artificial intelligence (AI) methods can ...

The identification of immunogenic epitopes (such as fragments of proteins, in particular peptides, that can trigger an immune response) is a fundamental need for immune-based therapies. A computational tool that could ...

Metagenomics is a pioneering branch of bioinformatics that utilizes genomics techniques, like the sequencing of the DNA, in order to obtain important information about microorganisms. During the recent years, scientists ...