The Piwi-interacting RNA (piRNA) system is an evolutionarily conserved mechanism involved
in the control of transposable elements and maintenance of genomic stability, especially in germ
line cells and in early embryo ...
Cancer research is continuously shedding light into these worldwide leading diseases. It is mandatory to have higher knowledge in cancer biology to consequently find out new candidate biomarkers and therapeutics. Among all ...
Breast cancer is the most common diagnosed cancer and the leading cause of cancer death among females worldwide. It is considered a highly heterogeneous disease and it must be classified into more homogeneous groups. Hence, ...
Cystic fibrosis (CF) is a genetic disease characterized by the formation of thick secretions
in the gut and airways, among other anatomical locations, which leads to an altered
microbiota. Understanding the significance ...
In the past decades, many breast cancer treatments have been approved. Although an effort has been
done to identify sensitive patients to specific treatments, such as targeted therapies like poly(ADP-ribose)
polymerases ...
Diabetic retinopathy is the leading cause of visual loss in individuals under the age of 55. Most investigations into the pathogenesis of diabetic retinopathy have been concentrated on the neural retina since this is where ...
Background: With the wide-spreading in high-throughput technologies and the arrival of omics era, new bioinformatics tools are available for the integration of different data types. Epidemiological and translational ...
To move toward a molecular taxonomy, we investigated three genome-wide platform
data, integrated as an unified categorical code called gene configuration. We
performed a multidimensional analysis of the gene configuration ...
Irritable bowel syndrome (IBS) is a chronic gastrointestinal disorder representing a serious burden to the
healthcare system. IBS research is extremely challenging due to the multifactorial etiology of the disease
and ...
Human cells contain seven somatic histone H1 variants (H1.1 to H1.5, H1.0 and H1X). Although some
advances have been recently achieved in the understanding of the H1 subtypes genomic distribution,
whether they present ...
Abstract
When we compare an individual’s genome with the reference, several mutations are encountered. Most of these mutations are neutral, but some others can lead to pathogenic consequences. Given the rapid increase in ...
Medulloblastoma (MB) is the most common malignant brain tumor in children and presents a varied
prognosis, with some patients succumbing to the disease and survivors presenting neurotoxic sequelae
from treatment. ...
Using network analysis in the study of chromatin 3D structure has proved to be a powerful and useful
approach. In order to determine which factors bound to DNA might play a role in establishing these 3D
chromatin structure, ...
The main goal of this project is to validate and compare machine learning methods to perform GWAS analysis. This study worked with genomic data on Alzheimer’s disease (AD). The data obtained was imputed by the Michigan ...
Abstract: Endocrine therapy (ET) combined with cyclin-dependent kinase 4/6 inhibitors (CDK4/6i) is the
standard treatment for metastatic estrogen receptor-positive (ER+) breast cancer. However, not all patients require
this ...
DNA methylation is the most studied epigenetic mark. It affects gene expression and has an im-portant role in several disorders. EWAS are performed to find associations between DNA methylation alterations and a given ...
Alzheimer disease (AD) is associated with distinctive changes in DNA methylation patterns.
DNA methylation is a chemical modification that is involved in gene silencing. These modifications
give rise to heritable changes ...
G protein-coupled receptors (GPCRs) form the largest family of membrane proteins in the human genome and are involved in important physiological functions. Therefore, they are very attractive pharmacological targets for ...
The advent of Oxford Nanopore Technologies is expected to play a pivotal role in near future
sequencing studies. Omics data analysis and related processes, currently bound to Next
Generation Sequencing, can be now ...