Introduction: Complex traits are determined by both genetic and environmental factors, as well as by their interactions (GxE). Maternal smoking during pregnancy is one of the most relevant exposures with both short- ...

Clopidogrel is a widely used antiplatelet drug used in preventing vascular events after suffering a first stoke. Genome-wide association studies (GWAS) has not been able to establish a clear association between polymorphisms ...

Background: The field of transcriptomics has developed an exponential growth in the last years thanks to the advances in high throughput RNA sequencing (RNAseq), which is becoming more popular as the cost is decreasing. ...

Colorectal cancer (CRC) is the third most common cancer and the fourth leading cause of cancer death worldwide. About 85% of the cases of CRC are known to have chromosomal instability, an allelic imbalance at several ...

Introduction: Gut microbiota plays an important role in humans. Its composition changes from birth to adulthood. Type of delivery, antibiotics use, diet, obesity, and host genetics, among others have been associated with ...

Cellular Indexing of Transcriptomes and Epitopes by Sequencing (CITE-sequencing) is a multimodal highthroughput single-cell technology that measures contemporaneously gene and surface protein expression levels for each ...

RNA-sequencing for detecting changes between expression patterns has emerged as a frequent tool in life sciences stud- ies. However, it is an under-development tool which still lacks a standard procedure. This way, many ...

Abstract Motivation: Some genes, termed 'biphasic genes', can transition between a preventive and promoting effect on disease recurrence during cancer progression. Identifying these genes poses substantial challenges for ...

Understanding the regulatory machinery is one of the current challenges for research in cancer epigenomics. Regulation of gene expression is a complex process with many components involved in it such as histone ...

Background: Imaging genetics (IG) studies aim to jointly analyse neuroimaging and genetic data with the objective of discovering new genetic variations related to brain features. Most IG studies focus on the individual ...