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Application of Multi-SNP Approaches Bayesian LASSO and AUC-RF to Detect Main Effects of Inflammatory-Gene Variants Associated with Bladder Cancer Risk

López de Maturana, Evangelina; Ye, Yuanging; Calle, M. Luz; Rothman, Nathaniel; Urrea Gales, Víctor; Kogevinas, Manolis; Petrus, Sandra; Chanock, Stephen; Tardón, Adonina; García-Closas, Montserrat; González-Neira, Anna; Vellalta, Gemma; Carrato, Alfredo; Navarro, Arcadi; Lorente-Galdós, Belén; Silverman, Debra T.; Real, Francisco X.; Wu, Xifeng; Malats i Riera, Núria (Public Library of Science, 2013)

The relationship between inflammation and cancer is well established in several tumor types, including bladder cancer. We performed an association study between 886 inflammatory-gene variants and bladder cancer risk in ...
AUC-RF: A New Strategy for Genomic Profiling with Random Forest

Calle, M. Luz; Urrea Gales, Víctor; Boulesteix, Anne-Laure; Malats i Riera, Núria (Karger, 2011)

Objective: Genomic profiling, the use of genetic variants at multiple loci simultaneously for the prediction of disease risk, requires the selection of a set of genetic variants that best predicts disease status. The ...
Gene Ontology Function prediction in Mollicutes using Protein-Protein Association Networks

Gómez Moruno, Antonio; Cedano, Juan; Amela, Isaac; Planas, Antoni (Planas Sauter); Piñol, Jaume (BioMed Central, 2011)

Abstract Background: Many complex systems can be represented and analysed as networks. The recent availability of large-scale datasets, has made it possible to elucidate some of the organisational principles and rules ...
Improving strategies for detecting genetic patterns of disease susceptibility in association studies

Calle, M. Luz; Urrea Gales, Víctor; Vellalta, Gemma; Malats i Riera, Núria; Steen, K.V. (Wiley InterScience, 2008)

The analysis of gene interactions and epistatic patterns of susceptibility is especially important for investigating complex diseases such as cancer characterized by the joint action of several genes. This work is motivated ...
Integrative analysis of the Regulatory Region of the FGFR3 Oncogene

Bau i Macià, Josep; Cullell i Dalmau, Marta; Solé-Casals, Jordi (Springer, 2011)

The study of transcriptional regulation often needs the integration of diverse yet independent data. In the present work, sequence conservation, predic-tion of transcription factor binding sites (TFBS) and gene expression ...
mbmdr: an R package for exploring gene–gene interactions associated with binary or quantitative traits

Calle, M. Luz; Urrea Gales, Víctor; Malats i Riera, Núria; Van Steen, Kristel (Oxford University Press, 2010)

Summary: We describe mbmdr, an R package for implementing the model-based multifactor dimensionality reduction (MB-MDR) method. MB-MDR has been proposed by Calle et al. as a dimension reduction method for exploring ...
Proposal, evaluation and application of two new methodologies for genetic profiling in association studies

Urrea Gales, Víctor (Universitat de Vic - Universitat Central de Catalunya, 22-04-2015)

L'objectiu de l'epidemiologia genètica és comprendre els efectes dels gens i els factors ambientals en la salut humana. Un aspecte important és l’estudi del paper de la variabilitat genètica en el risc de malalties comunes ...

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Consulteu Recerca per matèria "Genètica"

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