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Browsing by Author "Ouchi, Dan"

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Different Plasma Markers of Inflammation Are Influenced by Immune Recovery and cART Composition or Intensification in Treated HIV Infected Individuals

Massanella, Marta; Ouchi, Dan; Marfil, Sílvia; Llibre, Josep M.; Puertas, M.C.; Buzon, Maria J.; Richman, Douglas D.; Orna, Elisa; Stevenson, Mario; Gatell, J.M.; Domingo, Pere; Negredo, Eugenia; Martinez Picado, Francisco Javier; Clotet, Bonaventura; Blanco, Julià (Public Library of Science, 2014)

Abstract Background HIV-1 infection increases plasma levels of inflammatory markers. Combination antiretroviral therapy (cART) does not restore inflammatory markers to normal levels. Since intensification of cART ...
Effect of lithium on HIV-1 expression and proviral reservoir size in the CD4R T cells of antiretroviral therapy suppressed patients

Puertas, M.C.; Salgado, Maria; Morón López, Sara; Ouchi, Dan; Muñoz-Moreno, José A.; Clotet, Bonaventura; Martinez Picado, Francisco Javier (Lippincott Williams & Wilkins, 2014)

Previous in-vitro data pointed out lithium, an activator of the b-catenin signalling pathway, as a modulator of HIV-1 transcription. We assessed the effect of in-vivo administration of lithium on viral latency modulation ...
Establishment and replenishment of the viral reservoir in perinatally HIV-1-infected children initiating very early antiretroviral therapy

Martínez-Bonet, Marta; Puertas, M.C.; Fortuny, Claudia; Ouchi, Dan; Mellado, Maria José; Rojo, Pablo; Noguera-Julian, Antoni; Muñoz Fernández, María Ángeles; Martinez Picado, Francisco Javier (Oxford University Press, 2015)

Background. Combination antiretroviral therapy (cART) generally suppresses the replication of the human immunodeficiency virus type 1 (HIV-1) but does not cure the infection, because proviruses persist in stable ...
HIV-1 immune activation induces siglec-1 expression and enhances viral trans-infection in blood and tissue myeloid cells

Pino, Maria; Erkizia, Itziar; Benet, Susana; Erikson, Elina; Fernández Figueras, María Teresa; Guerrero, Dolores; Dalmau, Judith; Ouchi, Dan; Rausell, Antonio; Ciuffi, Angela; Keppler, Oliver T.; Telenti, Amalio; Kräusslich, H.G.; Martinez Picado, Francisco Javier; Izquierdo Useros, Nuria (BioMed Central, 2015)

Background: Myeloid cells are key players in the recognition and response of the host against invading viruses. Paradoxically, upon HIV-1 infection, myeloid cells might also promote viral pathogenesis through trans-infection, ...
Increased ex vivo cell death of central memory CD4 T cells in treated HIV infected individuals with unsatisfactory immune recovery

Massanella, Marta; Gómez-Mora, Elisabet; Carrillo, Jorge; Curriu, Marta; Ouchi, Dan; Puig, Jordi; Negredo, Eugenia; Cabrera, Cecilia; Clotet, Bonaventura; Blanco, Julià (Biomed central, 2015)

Abstract Background: High levels of ex vivo CD4 T-cell death and the accumulation of highly differentiated and/or immunosenescent T cells have been associated with poor CD4 T-cell recovery in treated HIV-infected ...
Viral and inflammatory markers in cerebrospinal fluid of patients with HIV-1-associated neurocognitive impairment during antiretroviral treatment switch

Tiraboschi, Juan M.; Muñoz-Moreno, José A.; Puertas, M.C.; Alonso-Villaverde, C.; Prats, A.; Ferrer, Elena; Rozas N.; Masó, Margarita; Ouchi, Dan; Martinez Picado, Francisco Javier; Podzamczer Palter, Daniel (Wiley, 2015)

Objectives: The aim of the study was to evaluate HIV-1 viral load (VL) and inflammatory markers in cerebrospinal fluid (CSF) and neurocognitive performance in patients with neurocognitive impairment (NCI) while they were ...

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Browsing by Author "Ouchi, Dan"

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