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Consulteu per matèria "Càncer -- Aspectes genètics"

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Genetic Variation in the TP53 Pathway and Bladder Cancer Risk. A Comprehensive Analysis

Pineda, S.; Milne, R.L.; Calle, M. Luz; Rothman, Nathaniel; López de Maturana, Evangelina; Herranz, J.; Kogevinas, Manolis; Chanock, Stephen; Tardón, Adonina; Márquez, M.; Guey, Lin T.; García-Closas, Montserrat; Lloreta, Josep; Baum, E.; González-Neira, Anna; Carrato, Alfredo; Navarro, Arcadi; Silverman, Debra T.; Real, Francisco X.; Malats i Riera, Núria (Public Library of Science, 2014)

Introduction: Germline variants in TP63 have been consistently associated with several tumors, including bladder cancer, indicating the importance of TP53 pathway in cancer genetic susceptibility. However, variants in ...
IKBα and Cancer

Rius Rafael, Cristina (01-10-2013)

It has been previously described that although phosphorylation of S32,36 is the instructive mark that targets IKBα for K21,22 ubiquitination and its subsequent degradation by the proteasome, K21,22 sumoylation protects ...
Insights into the transcriptomic effects of olaparib response on a breast cancer preclinical model

Clavell Revelles, Pau (09-2022)

In the past decades, many breast cancer treatments have been approved. Although an effort has been done to identify sensitive patients to specific treatments, such as targeted therapies like poly(ADP-ribose) polymerases ...
Machine learning-based gene expression signature for classification of endocrine therapy sensitivity in ER+ breast cancer patients

Flamen, Giles (10-09-2023)

Abstract: Endocrine therapy (ET) combined with cyclin-dependent kinase 4/6 inhibitors (CDK4/6i) is the standard treatment for metastatic estrogen receptor-positive (ER+) breast cancer. However, not all patients require this ...
Refining the genomic landscape of pediatric and young adult aggressive B-cell lymphomas

Colmenero Cobo de Gúzman, Ariadna (12-09-2022)

Aggressive B-cell non-Hodgkin lymphomas in children and young adults (CAYA) include the genetically well-defined Burkitt lymphoma (BL) and diffuse large B-cell lymphoma (DLBCL). Additionally, a group of highly proliferative ...
Susceptibilitat genètica al càncer gàstric: caracterització de les interaccions de segon ordre entre gens i variants identificades en l’estudi EPIC‐EURGAST

Ros i Rocher, Núria Montserrat (18-06-2013)

En aquest Treball de Final de Grau s’exposen els resultats de l’anàlisi de les dades genètiques del projecte EurGast2 "Genetic susceptibility, environmental exposure and gastric cancer risk in an European population”, ...
The effect of BRD4-NUT fusion on replication stress status of the NUT carcinoma

Ruiz Alías, Gabriel (06-2022)

El carcinoma NUT (NC) és un tipus de càncer humà rar i molt agressiu provocat per reordenacions genòmiques, que resulten en fusions entre el gen específic de testicles NUT i gens codificants per reguladors epigenètics, ...
Transcriptomic analysis of BRCA1 and BRCA2 carriers

Vilardell Lladó, Marina (01-09-2023)

Most frequently mutations that lead to the development of breast and ovarian cancer are BRCA1 and BRCA2. Blood samples from BRCA1, BRCA2 and non-mutation carriers were extracted for both healthy and cancer-affected ...

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Consulteu per matèria "Càncer -- Aspectes genètics"

Consulteu per matèria "Càncer -- Aspectes genètics"

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